Preclinical Data 2017-03-31T20:26:30+00:00

Preclinical Study

A preclinical animal study published in Muscles, Ligaments and Tendons Journal confirms the ability of the Rotation Medical bioinductive implant to generate reproducibly a layer of dense, regularly-oriented connective tissue (histologically similar to tendon) over the surface of a rotator cuff tendon in a sheep model.


  • Rapid incorporation of the collagen scaffold by host tissues
  • Scaffold stimulated both an inductive and conductive response
  • Consistent production of a dense, regularly-oriented, connective tissue layer suggests functional adaptation, remodeling and maturation
  • Excellent integration into bone with a fibrocartilagenous transition zone reminiscent of a normal direct insertion
  • No histologic evidence of a foreign body or inflammatory response at any time for any of the animals
  • Histologic response of the host remained stable at 1 year